Schimz K L
Arch Microbiol. 1980 Mar;125(1-2):89-95. doi: 10.1007/BF00403203.
After a short period of tolerance, living cells of Saccharomyces cerevisiae were irreversibly damaged by low concentrations of sulfite. The length of the period of tolerance and the rate of the damaging effect depended on the concentration on sulfite, pH-value, temperature, the physiological state of the cells, and incubation time. Inhibitors of protein synthesis and mitochondrial ATP synthesis did not alter the deleterious effect of sulfite on living cells. Furthermore, cell damage leading to inhibition of colony formation occured under aerobic as well as under anaerobic conditions. Prior to cell inactivation sulfite induced the formation of respiratory deficient cells. The active agent was shown to be SO2.
经过短时间的耐受后，低浓度的亚硫酸盐会使酿酒酵母的活细胞受到不可逆的损伤。耐受期的长短和损伤效应的速率取决于亚硫酸盐的浓度、pH值、温度、细胞的生理状态以及孵育时间。蛋白质合成抑制剂和线粒体ATP合成抑制剂不会改变亚硫酸盐对活细胞的有害作用。此外，无论是在需氧还是厌氧条件下，都会发生导致菌落形成受抑制的细胞损伤。在细胞失活之前，亚硫酸盐会诱导呼吸缺陷型细胞的形成。已证明活性剂是SO₂。
