白色念珠菌的萌发与对人颊黏膜上皮细胞黏附增加之间的关系。
Relationship between germination of Candida albicans and increased adherence to human buccal epithelial cells.
作者信息
Kimura L H, Pearsall N N
出版信息
Infect Immun. 1980 May;28(2):464-8. doi: 10.1128/iai.28.2.464-468.1980.
Abstract
A strong correlation was shown between germination and increased adherence of Candida albicans to human buccal epithelial cells, indicating that germination or other changes in the fungi accompanying germination were responsible for enhanced adherence. Partial inhibition of germination by cysteine resulted in a comparably lower adherence. Preferential adherence of germinated fungi occurred in competition assays with nongerminated and germinated fungi. The enhanced adherence to human mucosal cells of germinated C albicans could represent one mechanism contributing to the pathogenicity of the organism.
摘要
白色念珠菌的发芽与对人颊上皮细胞黏附增加之间呈现出强相关性，这表明发芽或伴随发芽的真菌其他变化是黏附增强的原因。半胱氨酸对发芽的部分抑制导致黏附程度相对较低。在非发芽和发芽真菌的竞争试验中，发芽真菌出现优先黏附现象。发芽的白色念珠菌对人黏膜细胞黏附增强可能是该生物体致病性的一种机制。
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