Hanssen L E, Kåresen R, Aune S
Scand J Gastroenterol. 1980;15(4):471-9. doi: 10.3109/00365528009181503.
Oral intake of glucose increased the peripheral plasma immunoreactive secretin (IRS) concentration in patients after total pancreatectomy with duodenectomy (p < 0.05) and in patients after total gastrectomy (p < 0.01). In young healthy volunteers and in patients after partial gastrectomy, no effect on IRS was observed. Intravenous glucose reduced the IRS concentration in pancreatectomized patients (p < 0.05), whereas IRS was only reduced in young healthy volunteers when intravenous glucose was followed by oral glucose after an interval of 10 min (p < 0.025). The abnormal IRS release in pancreatectomized patients and in patients after total gastrectomy might be due to rapid intestinal passage and/or increased splanchnic blood flow induced by hypertonic glucose. A third possibility is that a glucose-induced increase in bile flow might release IRS.
全胰十二指肠切除术后患者和全胃切除术后患者口服葡萄糖后，外周血浆免疫反应性促胰液素（IRS）浓度升高（全胰十二指肠切除术后患者：p < 0.05；全胃切除术后患者：p < 0.01）。在年轻健康志愿者和部分胃切除术后患者中，未观察到对IRS有影响。静脉注射葡萄糖可降低胰腺切除术后患者的IRS浓度（p < 0.05），而在年轻健康志愿者中，静脉注射葡萄糖10分钟后再口服葡萄糖，IRS才会降低（p < 0.025）。胰腺切除术后患者和全胃切除术后患者IRS释放异常，可能是由于高渗葡萄糖引起的肠道快速通过和/或内脏血流增加。第三种可能性是，葡萄糖诱导的胆汁流量增加可能会释放IRS。
