Petersen J, Andersen V, Bendixen G, Bendtzen K, Halkjaer-Kristensen J, Ingemann-Hansen T, Wiik A
Scand J Rheumatol. 1982;11(2):75-80. doi: 10.3109/03009748209098166.
The activity of blood mononuclear cells (BMC) and synovial fluid mononuclear cells (SMC) from patients with rheumatoid arthritis (RA) and traumatic synovitis (TS) was assessed by means of [14C]thymidine incorporation and production of leukocyte migration inhibitory factor (LIF). When compared with normal controls, spontaneous LIF production by BMC was found in 5 of 9 TS patients, whereas spontaneous LIF production by rheumatoid arthritis BMC and by SMC from both patient groups was infrequently seen. ConA-induced LIF production by BMC and SMC from both patient groups did not differ significantly from that of normal controls. Thymidine incorporation by unstimulated SMC and BMC was low in both patient groups. After stimulation with polyclonal activators, SMC showed significantly reduced proliferation in comparison with BMC, but the responses to microbial antigens were equal to or higher than those of BMC. The proliferative responses of stimulated SMC from TS patients were higher than the responses displayed by stimulated SMC from RA patients.
通过[14C]胸腺嘧啶核苷掺入法和白细胞迁移抑制因子（LIF）生成法，评估了类风湿性关节炎（RA）患者和创伤性滑膜炎（TS）患者的血液单核细胞（BMC）及滑液单核细胞（SMC）的活性。与正常对照组相比，9例TS患者中有5例的BMC出现自发LIF生成，而类风湿性关节炎患者的BMC以及两组患者的SMC很少出现自发LIF生成。两组患者的BMC和SMC经刀豆蛋白A诱导的LIF生成与正常对照组相比无显著差异。两组患者未受刺激的SMC和BMC的胸腺嘧啶核苷掺入率均较低。用多克隆激活剂刺激后，与BMC相比，SMC的增殖显著降低，但对微生物抗原的反应与BMC相当或更高。TS患者受刺激的SMC的增殖反应高于RA患者受刺激的SMC所显示的反应。
