类风湿关节炎中滑膜液B淋巴细胞的自发和诱导性免疫球蛋白分泌

Spontaneous and induced immunoglobulin secretion by synovial fluid B lymphocytes in rheumatoid arthritis.

作者信息

Petersen J, Ingemann-Hansen T, Halkjaer-Kristensen J S

出版信息

Ann Rheum Dis. 1984 Apr;43(2):140-5. doi: 10.1136/ard.43.2.140.

DOI:10.1136/ard.43.2.140

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1001450/

Abstract

The functional properties of B lymphocytes in synovial fluid (SF) from patients with rheumatoid arthritis (RA) were analysed by means of a reverse haemolytic plaque forming cell (PFC) assay. SF mononuclear cells spontaneously secreted IgG, but little IgM or IgA. The SF cells failed to respond to the polyclonal B cell activators pokeweed mitogen (PWM) and Epstein-Barr virus. However, SF B cells cocultured with autologous T lymphocytes from the blood and stimulated with PWM secreted IgG but little IgM or IgA. The PFC responses of blood B cells cocultured with autologous SF T cells in the presence of PWM were low; irradiation of the T cells increased the blood B lymphocyte responses, but the differences were not statistically significant. It is concluded that suppressor SF T cells may be partly responsible for the poor response of SF B cells to PWM.

摘要

通过反向溶血空斑形成细胞（PFC）试验分析了类风湿性关节炎（RA）患者滑液（SF）中B淋巴细胞的功能特性。滑液单核细胞自发分泌IgG，但很少分泌IgM或IgA。滑液细胞对多克隆B细胞激活剂商陆有丝分裂原（PWM）和爱泼斯坦-巴尔病毒无反应。然而，与来自血液的自体T淋巴细胞共培养并用PWM刺激的滑液B细胞分泌IgG，但很少分泌IgM或IgA。在PWM存在下与自体滑液T细胞共培养的血液B细胞的PFC反应较低；T细胞照射增加了血液B淋巴细胞反应，但差异无统计学意义。得出的结论是，抑制性滑液T细胞可能部分导致了滑液B细胞对PWM反应不佳。

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J Immunol. 1982 Jan;128(1):351-4.

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Influence of autologous monocytes on the pokeweed mitogen-induced generation of immunoglobulin-secreting cells in man.自体单核细胞对人商陆丝裂原诱导的免疫球蛋白分泌细胞生成的影响。

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