新型口服头孢菌素抗生素头孢克洛的体外活性
In vitro activity of cefaclor, a new orally administered cephalosporin antibiotic.
作者信息
Santoro J, Levison M E
出版信息
Antimicrob Agents Chemother. 1977 Sep;12(3):442-3. doi: 10.1128/AAC.12.3.442.
Abstract
The in vitro antibacterial activity of cefaclor, cephalothin, and cephalexin against 261 clinical isolates of Staphylococcus aureus and Enterobacteriaceae was compared. Cefaclor and cephalexin were about equally active against S. aureus. Cefaclor was the most active cephalosporin against Escherichia coli, Proteus mirabilis, and Klebsiella pneumoniae. The effect on the antimicrobial activity using a relatively high and low inoculum was pronounced for cefaclor when compared with that of cephalothin.
摘要
比较了头孢克洛、头孢噻吩和头孢氨苄对261株金黄色葡萄球菌和肠杆菌科临床分离株的体外抗菌活性。头孢克洛和头孢氨苄对金黄色葡萄球菌的活性大致相当。头孢克洛是对大肠杆菌、奇异变形杆菌和肺炎克雷伯菌活性最强的头孢菌素。与头孢噻吩相比，使用相对高接种量和低接种量时，头孢克洛对抗菌活性的影响更为显著。
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