Cramer D W, Welch W R, Scully R E, Wojciechowski C A
Cancer. 1982 Jul 15;50(2):372-6. doi: 10.1002/1097-0142(19820715)50:2<372::aid-cncr2820500235>3.0.co;2-s.
Opportunities for genital exposure to talc were assessed in 215 white females with epithelial ovarian cancers and in 215 control women from the general population matched by age, race, and residence. Ninety-two (42.8%) cases regularly used talc either as a dusting powder on the perineum or on sanitary napkins compared with 61 (28.4%) controls. Adjusted for parity and menopausal status, this difference yielded a relative risk of 1.92 (P less than 0.003) for ovarian cancer associated with these practices. Women who had regularly engaged in both practices had an adjusted relative risk of 3.28 (P less than 0.001) compared to women with neither exposure. This provides some support for an association between talc and ovarian cancer hypothesized because of the similarity of ovarian cancer to mesotheliomas and the chemical relation of talc to asbestos, a known cause of mesotheliomas. The authors also investigated opportunities for potential talc exposure from rubber products such as condoms or diaphragms or from pelvic surgery. No significant differences were noted between cases and controls in these exposures, although the intensity of talc exposure from these sources was likely affected by variables not assessed in this study.
对215名患有上皮性卵巢癌的白人女性以及215名来自普通人群、在年龄、种族和居住地方面与之匹配的对照女性，评估了生殖器接触滑石粉的机会。92名（42.8%）病例定期使用滑石粉，要么用于会阴扑粉，要么用于卫生巾，相比之下，对照女性有61名（28.4%）。经产次和绝经状态调整后，这些行为与卵巢癌相关的相对风险为1.92（P<0.003）。与未接触过任何一种行为的女性相比，经常同时进行这两种行为的女性经调整后的相对风险为3.28（P<0.001）。由于卵巢癌与间皮瘤的相似性以及滑石粉与石棉（间皮瘤的已知病因）的化学关系，这为滑石粉与卵巢癌之间的关联假设提供了一些支持。作者还调查了从避孕套或子宫托等橡胶制品或盆腔手术中潜在接触滑石粉的机会。在这些接触方面，病例组与对照组之间未发现显著差异，尽管这些来源的滑石粉接触强度可能受到本研究未评估的变量的影响。
