Abramson J S, Lewis J C, Lyles D S, Heller K A, Mills E L, Bass D A
J Clin Invest. 1982 Jun;69(6):1393-7. doi: 10.1172/jci110580.
The present study examined the effect of various unopsonized strains of influenza A virus on release of myeloperoxidase (MPO) and acid phosphatase in polymorphonuclear leukocytes (PMNL). These results were correlated with the effect that these same viruses had on bactericidal activity in PMNL. Several strains of virus inhibited the fusion of azurophil granules with phagosomes containing Staphylococcus aureus. These same strains inhibited the extracellular release of MPO from PMNL (39-59%) and caused depressed killing (42-77%). In contrast, one of the influenza viruses (X-47a) did not inhibit PMNL MPO release or killing. The data indicate a close relationship between the ability of influenza virus to ablate normal intracellular lysosome-phagosome fusion with subsequent depression of bactericidal functions of PMNL.
本研究检测了多种未调理的甲型流感病毒株对多形核白细胞（PMNL）中髓过氧化物酶（MPO）和酸性磷酸酶释放的影响。这些结果与这些相同病毒对PMNL杀菌活性的影响相关。几种病毒株抑制嗜天青颗粒与含有金黄色葡萄球菌的吞噬体融合。这些相同的病毒株抑制MPO从PMNL的细胞外释放（39 - 59%）并导致杀菌能力降低（42 - 77%）。相比之下，一种流感病毒（X - 47a）不抑制PMNL的MPO释放或杀菌能力。数据表明流感病毒消除正常细胞内溶酶体 - 吞噬体融合的能力与随后PMNL杀菌功能降低之间存在密切关系。
