Pitcock J A, Brown P S, Rapp J P, Crofton J, Muirhead E E
Am J Pathol. 1982 Oct;109(1):123-8.
Two strains of rats, one genetically sensitive (the Dahl S rat) and the other resistant (the Dahl R rat) to the hypertensive effect of a high-salt diet were studied morphometrically for determination of whether any anatomic differences were present in the renomedullary interstitial cells (RICs) that might help explain these strain differences. The rats resistant to the hypertensive effects of sodium chloride had more RIC than those from the sensitive strain. In addition, they were more heavily granulated. These findings may be related to the known antihypertensive function of the RICs and may help explain observed differences in the prostaglandin metabolism of the Dahl S and R rats.
对两组大鼠进行了形态测量学研究，一组对高盐饮食的高血压作用具有遗传敏感性（Dahl S大鼠），另一组具有抗性（Dahl R大鼠），以确定肾髓质间质细胞（RICs）中是否存在任何解剖学差异，这些差异可能有助于解释这些品系差异。对氯化钠高血压作用具有抗性的大鼠比敏感品系的大鼠具有更多的RIC。此外，它们的颗粒更粗大。这些发现可能与RICs已知的抗高血压功能有关，并可能有助于解释在Dahl S和R大鼠中观察到的前列腺素代谢差异。
