Layde P M, Vessey M P, Yeates D
J Epidemiol Community Health. 1982 Dec;36(4):274-8. doi: 10.1136/jech.36.4.274.
During 1968-74, 17 032 women aged 25-39 years were recruited to the Oxford/Family Planning Association Contraceptive Study. By the end of August 1981, 227 of these women had suffered surgically confirmed gall-bladder disease during the follow-up period, an incidence of 1·47 per 1000 woman-years. Obesity was by far the strongest risk factor for gall-bladder disease, but late age at first term birth and cigarette smoking also had statistically significant independent effects. The influence of the use of oral contraceptives on risk was small.
在1968年至1974年期间，17032名年龄在25至39岁之间的女性被纳入牛津大学/计划生育协会避孕研究。到1981年8月底，在随访期间，这些女性中有227人患了经手术确诊的胆囊疾病，发病率为每1000妇女年1.47例。肥胖是胆囊疾病最主要的危险因素，但初产年龄较大和吸烟也有统计学上显著的独立影响。使用口服避孕药对风险的影响较小。
