甲醛在血液透析相关抗N抗体发病机制中的作用

Formaldehyde in the pathogenesis of hemodialysis-related anti-N antibodies.

作者信息

White W L, Miller G E, Kaehny W D

出版信息

Transfusion. 1977 Sep-Oct;17(5):443-7. doi: 10.1046/j.1537-2995.1977.17578014581.x.

DOI:10.1046/j.1537-2995.1977.17578014581.x

Abstract

The role of formaldehyde (CH2O) in the pathogenesis of anti-N-like antibodies found in patients on chronic hemodialysis was investigated. In vitro studies were performed by incubating MM cells in varying concentrations of CH2O for variable time periods, corresponding to conditions that occur in dialysis. This MM cells acquired reactivity to anti-N antibody. The antigenic shift is felt to occur from the interaction of CH2O with the terminal N-acetylneuraminic acid (sialic acid) groups of M substance, resulting in the exposure to an altered-N antigen that is immunogenically active. Through a similar mechanism, CH2O may also directly modify N substance.

摘要

研究了甲醛（CH₂O）在慢性血液透析患者体内发现的抗N样抗体发病机制中的作用。通过将骨髓瘤细胞（MM细胞）在不同浓度的CH₂O中孵育不同时间段进行体外研究，这些时间段与透析过程中出现的情况相对应。结果发现这些MM细胞获得了对抗N抗体的反应性。抗原性转变被认为是由于CH₂O与M物质的末端N-乙酰神经氨酸（唾液酸）基团相互作用而发生的，导致暴露于具有免疫活性的改变后的N抗原。通过类似的机制，CH₂O也可能直接修饰N物质。