Beitner H, Ringborg U, Wennersten G, Lagerlöf B
Br J Dermatol. 1981 Mar;104(3):289-94. doi: 10.1111/j.1365-2133.1981.tb00951.x.
Minimal erythema dose (MED), immediate pigment darkening (IPD) and skin typing were performed on 130 patients with malignant melanoma and on seventy-three controls. The tumours were histologically classified according to Clark as superficial spreading melanoma, nodular melanoma, and lentigo maligna melanoma. The tumours of twelve patients were not possible to classify. Patients belonging to skin type IV and patients with lentigo maligna melanoma had a significantly higher mean age. The IPD reaction was significantly higher in skin type II than in skin types III and IV both in patients and in controls. IPD and MED showed no significant correlation to age and sex. MED was significantly lower among patients with malignant melanoma than controls. These data indicate that light sensitivity is of aetiological importance in malignant melanoma.
对130例恶性黑色素瘤患者和73名对照者进行了最小红斑量（MED）、即刻色素沉着（IPD）和皮肤分型。肿瘤根据克拉克组织学分类为浅表扩散型黑色素瘤、结节型黑色素瘤和恶性雀斑样痣黑色素瘤。12例患者的肿瘤无法分类。IV型皮肤患者和恶性雀斑样痣黑色素瘤患者的平均年龄显著更高。患者和对照者中，II型皮肤的IPD反应均显著高于III型和IV型皮肤。IPD和MED与年龄和性别均无显著相关性。恶性黑色素瘤患者的MED显著低于对照者。这些数据表明光敏感性在恶性黑色素瘤的病因学中具有重要意义。
