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在白纹伊蚊细胞感染辛德毕斯病毒的过程中两种分泌型宿主蛋白的选择性消失。

Selective disappearance of two secreted host proteins in the course of Semliki Forest virus infection of Aedes albopictus cells.

作者信息

Reigel F, Koblet H

出版信息

J Virol. 1981 Jul;39(1):321-4. doi: 10.1128/JVI.39.1.321-324.1981.

DOI:10.1128/JVI.39.1.321-324.1981
PMID:7277579
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC171294/
Abstract

One secreted host protein of molecular weight 54,000 (SP 54) disappeared (from 24 to 48 h after infection) in Semliki Forest virus-infected Aedes albopictus cell clone C6/36 grown in both Mitsuhashi-Maramorosch basal medium and tissue culture medium 199 and reappeared when cells went into the permanently infected state. C6/36 is a high virus producer showing a cytopathic effect. A second secreted host protein of molecular weight 62,000 (SP 62) was prominent if cell clone C6/36 was grown in tissue culture medium 199. After infection in this medium, the protein showed a behavior similar to that described for SP 54. These secreted proteins were not affected in two original Aedes albopictus cell lines. SP 54 and SP 62 are monomeric proteins and structurally not related.

摘要

一种分子量为54,000的分泌型宿主蛋白（SP 54）在感染辛德毕斯病毒的白纹伊蚊细胞克隆C6/36中消失（感染后24至48小时），该细胞在三桥-马拉莫罗斯基基础培养基和199组织培养基中培养，当细胞进入持续感染状态时又重新出现。C6/36是一种高病毒产生株，具有细胞病变效应。如果细胞克隆C6/36在199组织培养基中培养，第二种分子量为62,000的分泌型宿主蛋白（SP 62）很突出。在这种培养基中感染后，该蛋白表现出与SP 54描述的行为相似。这些分泌蛋白在两种原始白纹伊蚊细胞系中不受影响。SP 54和SP 62是单体蛋白，在结构上没有关联。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6580/171294/7c5719ebba7e/jvirol00007-0331-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6580/171294/fa533772e640/jvirol00007-0330-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6580/171294/567a4905c1ca/jvirol00007-0330-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6580/171294/7c5719ebba7e/jvirol00007-0331-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6580/171294/fa533772e640/jvirol00007-0330-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6580/171294/567a4905c1ca/jvirol00007-0330-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6580/171294/7c5719ebba7e/jvirol00007-0331-a.jpg

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本文引用的文献

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Nucleotide sequence of cdna coding for Semliki Forest virus membrane glycoproteins.编码Semliki森林病毒膜糖蛋白的cDNA的核苷酸序列。
Nature. 1980 Nov 20;288(5788):236-41. doi: 10.1038/288236a0.
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Cleavage of structural proteins during the assembly of the head of bacteriophage T4.在噬菌体T4头部组装过程中结构蛋白的切割
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Isolation of chikungunya virus contaminating an Aedes albopictus cell line.分离污染白纹伊蚊细胞系的基孔肯雅病毒。
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Fluorographic detection of radioactivity in polyacrylamide gels with the water-soluble fluor, sodium salicylate.使用水溶性荧光剂水杨酸钠对聚丙烯酰胺凝胶中的放射性进行荧光检测。
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Structure and replication of alpha-viruses.α病毒的结构与复制
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Plaque production by arboviruses in Singh's Aedes albopictus cells.虫媒病毒在辛格白纹伊蚊细胞中产生噬菌斑
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Sindbis virus-induced cytopathic effect in clones of Aedes albopictus (Singh) cells.辛德毕斯病毒在白纹伊蚊（辛格）细胞克隆中诱导的细胞病变效应。
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