Lee C L, Kamra O P
Hum Genet. 1981;57(4):380-4. doi: 10.1007/BF00281689.
The G-band pattern in 445 metaphases obtained seven weeks after irradiation (600 rad gamma-ray) was analysed. Approximately 37% of these cells had one or more structural aberrations. The majority of the aberrant events was reciprocal translocation followed by inversion and deletion in the proportion of 9:1:1 respectively. Statistical analyses (Chi-square tests) on the distribution of breakpoints among chromosomes showed an excess number of breaks in chromosomes 1, 7, and 12. Chromosomes 1 and 12 were particularly involved in cells carrying multiple aberrations while chromosome 7 was preferentially involved in deletion. Within chromosomes a significantly large number of breaks were located in (a) the light bands and (b) the terminal segments. The significance of these findings is discussed.
对辐照（600拉德γ射线）7周后获得的445个中期相的G带模式进行了分析。这些细胞中约37%有一个或多个结构畸变。大多数畸变事件是相互易位，其次是倒位和缺失，比例分别为9:1:1。对染色体间断点分布的统计分析（卡方检验）显示，1号、7号和12号染色体上的断点数量过多。1号和12号染色体特别涉及携带多个畸变的细胞，而7号染色体则优先涉及缺失。在染色体内，大量断点位于（a）浅带和（b）末端区段。讨论了这些发现的意义。
