Gibson T, Myers A R
J Rheumatol. 1981 Sep-Oct;8(5):752-9.
In a detailed retrospective analysis of 81 patients with systemic lupus erythematosus (SLE), elevated serum "liver enzymes" were recorded in 45 (55%) subjects. In 9 cases, the cause was non-hepatic and in 14 cases liver dysfunction was probably drug induced. Aspirin was the most common offender. Of the remaining 22 patients, 3 had congested livers secondary to heart failure and 19 had no obvious cause for liver dysfunction other than SLE itself. Liver histology was reviewed in 7 of these 19 patients. An inflammatory infiltrate of the portal areas was seen in 5, fatty liver in one and chronic active hepatitis in one. The frequency of liver dysfunction and the associated portal inflammation support the view that subclinical liver disease is a concomitant feature of SLE.
在一项对81例系统性红斑狼疮（SLE）患者的详细回顾性分析中，45例（55%）患者血清“肝酶”升高。9例病因与肝脏无关，14例肝功能障碍可能由药物引起。阿司匹林是最常见的致病药物。其余22例患者中，3例因心力衰竭导致肝脏充血，19例除SLE本身外无明显肝功能障碍病因。对这19例患者中的7例进行了肝脏组织学检查。5例可见门管区炎性浸润，1例为脂肪肝，1例为慢性活动性肝炎。肝功能障碍的发生率及相关的门管区炎症支持亚临床肝脏疾病是SLE伴随特征这一观点。
