Goosey J D, Zigler J S, Kinoshita J H
Science. 1980 Jun 13;208(4449):1278-80. doi: 10.1126/science.7375939.
In a dye-sensitized photooxidation system, lens crystallin polypeptides become cross-linked, and a blue fluorescence that is associated with the proteins is produced. These changes are similar to those seen in vivo in the aging human lens. Evidence implicating singlet oxygen as the causative agent of the effects in vitro is presented, and the possibility that this species may play a role in aging and cataractogenesis in vivo is discussed.
在染料敏化光氧化系统中，晶状体结晶蛋白多肽发生交联，并产生与蛋白质相关的蓝色荧光。这些变化与在衰老的人类晶状体体内观察到的变化相似。本文提供了单线态氧作为体外效应致病因子的证据，并讨论了该物质可能在体内衰老和白内障形成中发挥作用的可能性。
