Adinolfi M, Haddad S A
Neuropadiatrie. 1977 Nov;8(4):345-53. doi: 10.1055/s-0028-1091530.
High levels of albumin, alpha-fetoprotein (AFP), IgG, prealbumin and transferrin have been detected in cerebro-spinal fluid (CSF) of human fetuses between 14 and 25 weeks old. The concentration of each plasma protein in CSF was found to vary during the gestational period in relation to its serum levels and rate of synthesis and as a consequence of a reduced permeability of the blood-CSF barrier after 22 weeks. In fact, the higher CSF levels of AFP were detected in fetuses about 16 weeks old, while the highest values of albumin were observed in CSF from fetuses between 20 and 24 weeks old. Experimental work has shown that also in rats the permeability of the blood-CSF barrier is incomplete during fetal and perinatal life. When 125I-labelled albumin and IgG or 14C-oestrogen and testosterone were injected intraperitoneally in newborn rats, the labelled proteins and hormones were detected in fetal blood and CSF four hours after the injection. These results are discussed in view of the suggestion that maternal abnormal states with regard to hormones and antibrain antibodies may affect the development of the nervous system and unfolding of behaviour.
在14至25周龄的人类胎儿脑脊液（CSF）中检测到高水平的白蛋白、甲胎蛋白（AFP）、免疫球蛋白G（IgG）、前白蛋白和转铁蛋白。发现脑脊液中每种血浆蛋白的浓度在妊娠期会因血清水平、合成速率以及22周后血脑屏障通透性降低而发生变化。事实上，在约16周龄的胎儿中检测到脑脊液中AFP水平较高，而在20至24周龄胎儿的脑脊液中观察到白蛋白的最高值。实验研究表明，在大鼠中，血脑屏障在胎儿期和围产期的通透性也是不完全的。当给新生大鼠腹腔注射125I标记的白蛋白和IgG或14C标记的雌激素和睾酮时，注射后4小时在胎儿血液和脑脊液中检测到标记的蛋白质和激素。鉴于母体激素和抗脑抗体异常状态可能影响神经系统发育和行为表现的观点，对这些结果进行了讨论。
