Axelsson G, Rylander R, Schmidt A
Br J Ind Med. 1980 May;37(2):121-7. doi: 10.1136/oem.37.2.121.
ABSTRACT An investigation was carried out to determine the cause of death and the incidence of tumours among 1932 workers in a ferrochromium plant in Sweden. The workers had been exposed mainly to metallic and trivalent chromium (Cr); hexavalent chromium (Cr) was also present in certain working operations. The population was defined as all men employed at the plant for at least one year during 1930-75, and were classified according to their occupation within the industry. The causes of death were initially obtained from parish registers. For deaths occuring between 1951 and 1975, death certificates were collected from the National Central Bureau of Statistics. Data on the incidence of cancer during 1958-75 were obtained from the Swedish National Cancer Registry. Expected death rates and incidence of tumours were calculated, based on the rates for the county in which the factory was situated. The total number of deaths from tumours was less than expected (69 versus 76·7). Five cases of respiratory cancer were found, against an expected 7·2. Among maintenance workers, an increased death rate from all tumours and an increased number of respiratory tumours were found. Two of the latter were mesotheliomas and could be connected with asbestos exposure. No increase was found for respiratory tumours among the heavily exposed workers at the arc-furnaces; one case of mesothelioma was found in this group.
摘要 开展了一项调查，以确定瑞典一家铬铁厂1932名工人的死因和肿瘤发病率。这些工人主要接触金属铬和三价铬（Cr）；在某些作业中也存在六价铬（Cr）。研究人群定义为1930年至1975年期间在该厂工作至少一年的所有男性，并根据他们在该行业内的职业进行分类。死因最初来自教区登记册。对于1951年至1975年期间发生的死亡，从国家中央统计局收集了死亡证明。1958年至1975年期间的癌症发病率数据来自瑞典国家癌症登记处。根据工厂所在县的死亡率计算预期死亡率和肿瘤发病率。肿瘤死亡总数低于预期（69例对76.7例）。发现5例呼吸道癌症，预期为7.2例。在维修工人中，发现所有肿瘤的死亡率增加，呼吸道肿瘤数量增加。后者中有两例是间皮瘤，可能与接触石棉有关。在电弧炉旁接触严重的工人中，未发现呼吸道肿瘤增加；该组中发现1例间皮瘤。
