Resistance to amphotericin B associated with defective sterol delta 8-->7 isomerase in a Cryptococcus neoformans strain from an AIDS patient.

作者信息

Kelly S L, Lamb D C, Taylor M, Corran A J, Baldwin B C, Powderly W G

机构信息

Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, Sheffield University, UK.

出版信息

FEMS Microbiol Lett. 1994 Sep 15;122(1-2):39-42. doi: 10.1111/j.1574-6968.1994.tb07140.x.

Two Cryptococcus neoformans strains isolated from an AIDS patient were investigated, a pretreatment isolate (CN1) and a second isolate (CN3) following failure of fluconazole and amphotericin B treatment. No difference in fluconazole sensitivity, but relative resistance to amphotericin B was observed for CN3. The sterol composition of CN3 indicated a defect in sterol delta 8-->7 isomerase in this strain and depletion of ergosterol, the major sterol of the CN1.