Tietz H J, Küssner A, Thanos M, De Andrade M P, Presber W, Schönian G
Dermatologische Universitätsklinik und Poliklinik, Universitätsklinikum Charité, Humboldt-Universität, Berlin, Germany.
J Clin Microbiol. 1995 Sep;33(9):2462-5. doi: 10.1128/jcm.33.9.2462-2465.1995.
As expected by its global prevalence, the most frequently isolated species of yeast from vaginal swabs obtained from patients in Africa was Candida albicans, which accounted for 53 of 85 (62.4%) of the isolates from women in Madagascar and 35 of 54 (64.8%) of the culture-positive women in Angola. However, 40% of the Madagascan and 23% of the isolates from Angola, as well as two isolates obtained from one German patient, were not able to utilize the amino sugars glucosamine and N-acetylglucosamine as the sole carbon source. These isolates were able to form germ tubes but did not form chlamydospores. The correct identification as C. albicans was made possible only by using a PCR-based method of DNA fingerprinting. Only minor phenotypic and genotypic variation was observed among these strains. Whether they represent a distinct clone that is found mainly in Africa is not clear. The relevance of the amino sugar catabolic pathway in C. albicans is discussed in view of these results.
正如其全球流行情况所预期的那样，从非洲患者阴道拭子中分离出的最常见酵母菌种是白色念珠菌，在马达加斯加女性的85株分离菌中占53株（62.4%），在安哥拉培养阳性的54名女性中占35株（64.8%）。然而，马达加斯加分离菌的40%、安哥拉分离菌的23%，以及从一名德国患者身上获得的两株分离菌，不能利用氨基糖葡萄糖胺和N - 乙酰葡萄糖胺作为唯一碳源。这些分离菌能够形成芽管，但不形成厚壁孢子。只有通过基于PCR的DNA指纹图谱方法才能正确鉴定为白色念珠菌。在这些菌株中仅观察到微小的表型和基因型变异。它们是否代表主要在非洲发现的独特克隆尚不清楚。鉴于这些结果，讨论了白色念珠菌中氨基糖分解代谢途径的相关性。
