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皮质类固醇对中性粒细胞Fc受体功能的抑制作用。

Inhibition of neutrophil Fc receptor function by cotricosteroids.

作者信息

Klempner M S, Gallin J I

出版信息

Clin Exp Immunol. 1978 Oct;34(1):137-42.

PMID:750117
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1537461/
Abstract

The ability of hydrocortisone sodium succinate to inhibit the adherence of IgG-sensitized erythrocytes (EA) to human peripheral blood neutrophil monolayers is described. The steroid inhibitory effect was dose-dependent with a 32.4+/-2.4% decrease in EA binding at 2 X 10(-4)M. There was no difference between the addition of hydrocortisone prior to or at the same time as EA and steroid interference with EA binding was completely reversible. In addition, hydrocortisone was unable to displace bound EA. These findings suggest that hydrocortisone interferes with the availability of the neutrophil Fc receptor for binding and provides further insight into the host factors which are compromised during corticosteroid administration.

摘要

描述了氢化可的松琥珀酸钠抑制IgG致敏红细胞（EA）与人外周血中性粒细胞单层粘附的能力。类固醇的抑制作用呈剂量依赖性，在2×10（-4）M时EA结合减少32.4±2.4%。在EA之前或同时添加氢化可的松之间没有差异，并且类固醇对EA结合的干扰是完全可逆的。此外，氢化可的松不能取代结合的EA。这些发现表明，氢化可的松干扰中性粒细胞Fc受体的结合可用性，并进一步深入了解在使用皮质类固醇期间受到损害的宿主因素。

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FAILURE OF PRETREATMENT WITH GLUCOCORTICOIDS TO MODIFY THE PHAGOCYTIC AND BACTERICIDAL CAPACITY OF HUMAN LEUKOCYTES FOR ENCAPSULATED TYPE I PNEUMOCOCCUS.糖皮质激素预处理未能改变人类白细胞对I型包膜肺炎球菌的吞噬和杀菌能力。
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