Nieman D C, Buckley K S, Henson D A, Warren B J, Suttles J, Ahle J C, Simandle S, Fagoaga O R, Nehlsen-Cannarella S L
Department of Health, Leisure, and Exercise Science, Applachian State University, Boone, NC, USA.
Med Sci Sports Exerc. 1995 Jul;27(7):986-92. doi: 10.1249/00005768-199507000-00006.
Marathon runners (N = 22) who had completed at least seven marathons (X +/- SEM = 23.6 +/- 5.7) and had been training for marathon race events for at least 4 yr (12.3 +/- 1.3) were compared with sedentary controls (N = 18). Although the two groups were of similar age (38.7 +/- 1.5 and 43.9 +/- 2.2 yr, respectively) and height, the marathon runners were significantly leaner and possessed a VO2max 60% higher than that of the controls. Neutrophil counts tended to be lower in the group of marathoners, while other leukocyte and lymphocyte subsets were similar to controls. Mitogen-induced lymphocyte proliferation did not differ between groups. Natural killer cell cytotoxic activity (NKCA) was significantly higher in the marathoners versus controls (373 +/- 38 vs 237 +/- 41 total lytic units, respectively, a 57% difference, P = 0.02). For all subjects combined (N = 40) and within the group of marathon runners (N = 22), percent body fat was negatively correlated with NKCA (r = -0.48, P = 0.002; r = -0.49, P = 0.019, respectively), and age was negatively correlated with Con A-induced lymphocyte proliferation (r = -0.41, P = 0.009; r = -0.53, P = 0.011, respectively). These data indicate that NKCA but not mitogen-induced lymphocyte proliferation is higher in marathon runners relative to sedentary controls.
将至少完成过七次马拉松比赛（X +/- SEM = 23.6 +/- 5.7）且已进行至少4年（12.3 +/- 1.3）马拉松赛事训练的马拉松运动员（N = 22）与久坐不动的对照组（N = 18）进行比较。尽管两组年龄相似（分别为38.7 +/- 1.5岁和43.9 +/- 2.2岁）且身高相近，但马拉松运动员明显更瘦，其最大摄氧量比对照组高60%。马拉松运动员组的中性粒细胞计数往往较低，而其他白细胞和淋巴细胞亚群与对照组相似。两组间丝裂原诱导的淋巴细胞增殖无差异。与对照组相比，马拉松运动员的自然杀伤细胞细胞毒性活性（NKCA）显著更高（分别为373 +/- 38和237 +/- 41总裂解单位，差异为57%，P = 0.02）。对于所有受试者（N = 40）以及马拉松运动员组内（N = 22），体脂百分比与NKCA呈负相关（r = -0.48，P = 0.002；r = -0.49，P = 0.019），年龄与刀豆蛋白A诱导的淋巴细胞增殖呈负相关（r = -0.41，P = 0.009；r = -0.53，P = 0.011）。这些数据表明，相对于久坐不动的对照组，马拉松运动员的NKCA更高，但丝裂原诱导的淋巴细胞增殖无差异。
