患结肠癌风险高的人群的肠道菌群。
Intestinal floras of populations that have a high risk of colon cancer.
作者信息
Moore W E, Moore L H
机构信息
Anaerobe Laboratory, Virginia Polytechnic Institute and State University, Blacksburg 24061-0305, USA.
出版信息
Appl Environ Microbiol. 1995 Sep;61(9):3202-7. doi: 10.1128/aem.61.9.3202-3207.1995.
The fecal floras of polyp patients, Japanese-Hawaiians, North American Caucasians, rural native Japanese, and rural native Africans were compared. The polyp patients and Japanese-Hawaiians were considered to be groups at high risk of colon cancer, and the rural native Japanese and rural native Africans were considered to be groups at low risk. The North American Caucasians were found to have a flora composition intermediate between these two groups. Fifteen bacterial taxa from the human fecal flora were significantly associated with high risk of colon cancer, and five were significantly associated with low risk of colon cancer. Total concentrations of Bacteroides species and, surprisingly, Bifidobacterium species were generally positively associated with increased risk of colon cancer. Some Lactobacillus species and Eubacterium aerofaciens, which also produces major amounts of lactic acid, showed closest associations with low risk of colon cancer.
对息肉患者、日裔夏威夷人、北美白种人、日本农村原住民和非洲农村原住民的粪便菌群进行了比较。息肉患者和日裔夏威夷人被视为患结肠癌风险较高的群体，而日本农村原住民和非洲农村原住民被视为患结肠癌风险较低的群体。发现北美白种人的菌群组成介于这两组之间。人类粪便菌群中的15个细菌分类群与患结肠癌的高风险显著相关，5个与患结肠癌的低风险显著相关。拟杆菌属物种的总浓度，令人惊讶的是，双歧杆菌属物种的总浓度通常与患结肠癌风险的增加呈正相关。一些乳酸菌属物种和也产生大量乳酸的产气真杆菌与患结肠癌的低风险关系最为密切。
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