McDonald R J, White N M
Department of Psychology, McGill University, Montreal, Quebec, Canada.
Behav Neurosci. 1995 Aug;109(4):579-93. doi: 10.1037//0735-7044.109.4.579.
Brain structures thought to be critical for learning and memory were lesioned, and the effects on rats' ability to locate food on a radial maze in situations that provided different types of information was used to suggest general principles of information processing by hypothesized neural systems that include each of the lesioned structures. When animals were confined to food-containing and empty arms on different training trials, the learned discrimination between the arms was amygdala based. More training trials were required for ambiguous (adjacent arms) than for unambiguous (widely separated arms) discriminations. When rats moved around and entered both food and no-food arms on the same trial, the unambiguous discrimination was learned by both dorsal striatum- and hippocampus-based systems; however, the ambiguous discrimination was learned only by the hippocampus system.
被认为对学习和记忆至关重要的脑结构受到了损伤，通过观察在提供不同类型信息的情境中对大鼠在放射状迷宫中定位食物能力的影响，来推测包括每个受损结构在内的假设神经系统的信息处理一般原则。当动物在不同的训练试验中被限制在有食物和空的臂上时，对臂之间的习得性辨别是基于杏仁核的。与明确（相距很远的臂）辨别相比，模糊（相邻臂）辨别需要更多的训练试验。当大鼠在同一次试验中四处移动并进入有食物和无食物的臂时，明确辨别是由基于背侧纹状体和海马体的系统习得的；然而，模糊辨别仅由海马体系统习得。
