一名艾滋病患者的2型单纯疱疹病毒脑炎及合并巨细胞病毒感染：通过巢式聚合酶链反应检测脑脊液中病毒特异性DNA
Herpes simplex virus type 2 encephalitis and concomitant cytomegalovirus infection in a patient with AIDS: detection of virus-specific DNA in CSF by nested polymerase chain reaction.
作者信息
Miller R F, Fox J D, Waite J C, Severn A, Brink N S
机构信息
Department of Medicine, University College London Medical School, Middlesex Hospital, London, UK.
出版信息
Genitourin Med. 1995 Aug;71(4):262-4. doi: 10.1136/sti.71.4.262.
Abstract
A Caucasian homosexual man with AIDS and cytomegalovirus retinitis presented with facial pain and episodic confusion, had several seizures and became obtunded. An electroencephalogram was suggestive of herpes simplex encephalitis. The diagnosis was confirmed by detection of herpes simplex virus type 2 (HSV 2), but not type 1, DNA in cell-free cerebrospinal fluid (CSF) after amplification by nested polymerase chain reaction. The patient also had evidence of concomitant cytomegalovirus (CMV) infection with detectable CMV DNA in CSF. With high-dose acyclovir the patient recovered. Analysis of a follow up CSF sample taken four months later showed no detectable HSV-2 DNA.
摘要
一名患有艾滋病和巨细胞病毒性视网膜炎的白人同性恋男子出现面部疼痛和发作性意识模糊，有多次癫痫发作并变得迟钝。脑电图提示为单纯疱疹病毒性脑炎。通过巢式聚合酶链反应扩增后，在无细胞脑脊液（CSF）中检测到2型单纯疱疹病毒（HSV 2）而非1型单纯疱疹病毒的DNA，从而确诊。该患者同时有巨细胞病毒（CMV）感染的证据，脑脊液中可检测到CMV DNA。使用大剂量阿昔洛韦治疗后患者康复。四个月后采集的后续脑脊液样本分析显示未检测到HSV-2 DNA。
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