Patnaik M, Komaroff A L, Conley E, Ojo-Amaize E A, Peter J B
Specialty Laboratories, Inc., Santa Monica, California 90404-3900, USA.
J Infect Dis. 1995 Nov;172(5):1364-7. doi: 10.1093/infdis/172.5.1364.
To evaluate the association between human herpesvirus 6 (HHV-6) and chronic fatigue syndrome (CFS), 2 geographically separate groups of CFS patients (125 and 29 patients, respectively) and healthy controls (150 and 15 controls, respectively) were compared, using an EIA, for antibodies to HHV-6 early antigen p41/38 (EA). Sixty percent (93/154) of CFS patients were were positive for HHV-6 EA IgM, 40% (61/154) were positive for IgG, and 23% (35/154) were positive for both. A total of 119 (77%) of the CFS patients were positive for HHV-6 EA IgG or IgM (or both); only 12% (20/165) of the controls had IgG or IgM to HHV-6 EA. These data demonstrate that more CFS patients than controls had elevated levels of HHV-6 EA-specific IgM, perhaps indicating active replication of HHV-6 in CFS.
为评估人类疱疹病毒6型（HHV-6）与慢性疲劳综合征（CFS）之间的关联，使用酶免疫测定法（EIA）比较了两组地理位置不同的CFS患者（分别为125例和29例）以及健康对照者（分别为150例和15例）体内抗HHV-6早期抗原p41/38（EA）的抗体。60%（93/154）的CFS患者HHV-6 EA IgM呈阳性，40%（61/154）的患者IgG呈阳性，23%（35/154）的患者两者均呈阳性。共有119例（77%）CFS患者HHV-6 EA IgG或IgM（或两者）呈阳性；仅12%（20/165）的对照者体内有抗HHV-6 EA的IgG或IgM。这些数据表明，CFS患者中抗HHV-6 EA特异性IgM水平升高的人数多于对照者，这可能表明HHV-6在CFS患者体内活跃复制。
