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咖啡酰奎宁酸对单核细胞迁移和超氧阴离子产生的抑制作用研究。

Studies on the inhibitory effects of caffeoylquinic acids on monocyte migration and superoxide ion production.

作者信息

Peluso G, De Feo V, De Simone F, Bresciano E, Vuotto M L

机构信息

Istituto di Biochimica delle Proteine ed Enzimologia, Napoli, Italy.

出版信息

J Nat Prod. 1995 May;58(5):639-46. doi: 10.1021/np50119a001.

DOI:10.1021/np50119a001
PMID:7623043
Abstract

Three caffeoylquinic acids, isolated from the Peruvian plants Tessaria integrifolia and Mikania cordifolia that are used medicinally as anti-inflammatory agents, were tested for their activities on monocyte migration and superoxide anion production. 3,5-Di-O-caffeoylquinic and 4,5-di-O-caffeoylquinic acids exhibited an appreciable anti-inflammatory activity in vitro, while the tricaffeoyl derivative was inactive.

摘要

从秘鲁植物全缘特斯亚草和心叶蔓绿绒中分离出三种咖啡酰奎宁酸,这两种植物在医学上用作抗炎剂,对它们的单核细胞迁移和超氧阴离子产生活性进行了测试。3,5 - 二 - O - 咖啡酰奎宁酸和4,5 - 二 - O - 咖啡酰奎宁酸在体外表现出明显的抗炎活性,而三咖啡酰衍生物无活性。

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