Lovering R, Hanson I M, Borden K L, Martin S, O'Reilly N J, Evan G I, Rahman D, Pappin D J, Trowsdale J, Freemont P S
Human Immunogenetics Laboratory, Imperial Cancer Research Fund, London, United Kingdom.
Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2112-6. doi: 10.1073/pnas.90.6.2112.
We have identified a protein motif, related to the zinc finger, which defines a newly discovered family of proteins. The motif was found in the sequence of the human RING1 gene, which is proximal to the major histocompatibility complex region on chromosome six. We propose naming this motif the "RING finger" and it is found in 27 proteins, all of which have putative DNA binding functions. We have synthesized a peptide corresponding to the RING1 motif and examined a number of properties, including metal and DNA binding. We provide evidence to support the suggestion that the RING finger motif is the DNA binding domain of this newly defined family of proteins.
我们已鉴定出一种与锌指相关的蛋白质基序，它定义了一个新发现的蛋白质家族。该基序存在于人类RING1基因的序列中，该基因位于6号染色体上主要组织相容性复合体区域的近端。我们建议将此基序命名为“RING指”，它存在于27种蛋白质中，所有这些蛋白质都具有假定的DNA结合功能。我们合成了与RING1基序对应的肽，并研究了其一些特性，包括金属结合和DNA结合。我们提供证据支持RING指基序是这个新定义的蛋白质家族的DNA结合结构域这一观点。
