Kobayashi M, Aoki S, Gato K, Matsunami K, Kurosu M, Kitagawa I
Faculty of Pharmaceutical Sciences, Osaka University, Japan.
Chem Pharm Bull (Tokyo). 1994 Dec;42(12):2449-51. doi: 10.1248/cpb.42.2449.
A new antibiotic indole trimer named trisindoline (1) was isolated, together with a known dioxopiperazine brevianamide F (2), from the culture of a bacterium of Vibrio sp., which was separated from the Okinawan marine sponge Hyrtios altum. The structure of trisindoline (1) has been determined on the bases of physicochemical evidence and chemical synthesis.
从冲绳海洋海绵Hyrtios altum分离出的弧菌属细菌培养物中,分离出一种名为三吲哚啉(1)的新型抗生素吲哚三聚体,以及一种已知的二氧代哌嗪短杆菌肽F(2)。已根据物理化学证据和化学合成确定了三吲哚啉(1)的结构。