太空飞行对椎间盘成分的影响。

Department of Orthopaedic Surgery, University of Iowa, USA.

Iowa Orthop J. 1994;14:125-33.

The lumbar annuli of rats flown on a COSMOS space flight were compared with those of three control groups and a ground antigravity tail suspension model. The wet and dry weights of the space flight annuli were significantly smaller than the three control groups. In addition, the collagen-to-proteoglycan ratio was significantly greater in the flight group due to a proportional increase in collagen and a decrease in proteoglycan. Finally, it appears microgravity may have altered the nature of the proteoglycan population as more proteoglycans leached from the annuli of flight animals than control animals when immersed in water.

将在宇宙飞船上飞行过的大鼠的腰椎间盘纤维环与三个对照组以及地面抗重力尾部悬吊模型的纤维环进行了比较。太空飞行的纤维环的湿重和干重均显著小于三个对照组。此外，由于胶原蛋白成比例增加而蛋白聚糖减少，飞行组的胶原蛋白与蛋白聚糖的比例显著更高。最后，当浸入水中时，飞行动物的纤维环比对照动物的纤维环沥出更多的蛋白聚糖，这表明微重力可能改变了蛋白聚糖群体的性质。