Caulfield L E, Himes J H, Rivera J A
Division of Human Nutrition, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD 21205, USA.
J Nutr. 1995 Apr;125(4 Suppl):1104S-1110S. doi: 10.1093/jn/125.suppl_4.1104S.
To assess the long-term impact of nutritional supplementation on bone mineralization during adolescence, we studied 356 Guatemalan adolescents who participated from birth to 7 y of age in a controlled supplementation trial. Bone mineralization of the distal radius was assessed using single photon absorptiometry. Children who consumed more cumulative energy from the supplement during childhood had greater bone mineral content, bone width and bone mineral density during adolescence than those who consumed less energy. The associations remained after controlling for each subject's age and gender, and for the type of supplement consumed, but became statistically nonsignificant after adjusting for weight and stature. Because intake of supplement also was associated positively with weight and stature during adolescence, it is concluded that supplementing malnourished children can have a demonstrable long-term impact on bone mineralization, but that the effects are probably not beyond those due to improvements in overall somatic growth associated with supplementation.
为评估营养补充剂对青春期骨骼矿化的长期影响，我们研究了356名危地马拉青少年，他们从出生到7岁参与了一项对照补充试验。使用单光子吸收法评估桡骨远端的骨骼矿化情况。在儿童期从补充剂中摄入更多累积能量的儿童，在青春期的骨矿物质含量、骨宽度和骨矿物质密度均高于摄入能量较少的儿童。在控制了每个受试者的年龄和性别以及所摄入补充剂的类型后，这些关联仍然存在，但在调整体重和身高后，它们在统计学上变得不显著。由于补充剂的摄入量在青春期也与体重和身高呈正相关，因此得出结论，补充营养不良的儿童对骨骼矿化可产生明显的长期影响，但这种影响可能不会超过因补充剂带来的总体身体生长改善所产生的影响。
