Pickett K E, Haas J D, Murdoch S, Rivera J A, Martorell R
Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA.
J Nutr. 1995 Apr;125(4 Suppl):1097S-1103S. doi: 10.1093/jn/125.suppl_4.1097S.
The effect of early childhood nutritional supplementation on skeletal maturation at adolescence was investigated in 663 rural Guatemalans, aged 11-18 y. Skeletal maturation was assessed by the Tanner-Whitehouse-2 method. The subjects were former participants in the Institute of Nutrition of Central America and Panama longitudinal study of growth and development (1969-77) residing in four villages (two large and two small) in eastern Guatemala. The villages were randomized within pairs to receive either a high energy, high protein supplement (Atole) or a low energy supplement with no protein (Fresco). Skeletal maturity was observed across all villages to be delayed significantly relative to a British reference for boys < 14 y of age, but not for older boys or for girls < 14 y of age. Delays in girls > 14 years could not be determined reliably because many had reached maturity. Girls < 14 years from Atole villages were more advanced in skeletal maturity than similar age girls from Fresco villages but these differences were found only in comparisons of the large villages. The relationship between early nutrition and biological maturation at adolescence may be obscured in this sample by the advanced age at which the subjects were examined in adolescence.
在663名年龄在11至18岁的危地马拉农村青少年中，研究了幼儿期营养补充对青春期骨骼成熟的影响。采用坦纳 - 怀特豪斯 - 2方法评估骨骼成熟度。这些受试者曾参与中美洲和巴拿马营养研究所关于生长发育的纵向研究（1969 - 1977年），居住在危地马拉东部的四个村庄（两个大村庄和两个小村庄）。这些村庄被成对随机分组，分别接受高能量、高蛋白补充剂（阿托尔）或不含蛋白质的低能量补充剂（弗雷斯可）。相对于英国同龄男孩参考标准，所有村庄的骨骼成熟度在14岁以下男孩中显著延迟，但在年龄较大的男孩或14岁以下女孩中并非如此。14岁以上女孩的延迟情况无法可靠确定，因为许多人已经成熟。来自阿托尔村庄的14岁以下女孩在骨骼成熟度上比来自弗雷斯可村庄的同龄女孩更超前，但这些差异仅在大村庄的比较中发现。在这个样本中，青春期早期营养与生物成熟之间的关系可能因受试者在青春期接受检查时年龄较大而被掩盖。
