I型猫传染性腹膜炎病毒纤突蛋白基因的分子克隆与序列测定
Molecular cloning and sequence determination of the peplomer protein gene of feline infectious peritonitis virus type I.
作者信息
Motokawa K, Hohdatsu T, Aizawa C, Koyama H, Hashimoto H
机构信息
Department of Veterinary Infectious Diseases, School of Veterinary Medicine and Animal Sciences, Kitasato University, Tokyo, Japan.
出版信息
Arch Virol. 1995;140(3):469-80. doi: 10.1007/BF01718424.
Abstract
cDNA clones spanning the entire region of the peplomer (S) gene of feline infectious peritonitis virus (FIPV) type I strain KU-2 were obtained and their complete nucleotide sequences were determined. A long open reading frame (ORF) encoding 1464 amino acid residues was found in the gene, which was 12 residues longer than the ORF of the FIPV type II strain 79-1146. The sequences of FIPV type I and mainly -tPV type II were compared. The homologies at the N- (amino acid residues 1-693) and C- (residues 694-1464) terminal halves were 29.8 and 60.7%, respectively. This was much lower than that between FIPV type II and other antigenically related coronaviruses, such as transmissible gastroenteritis virus of swine and canine coronavirus. This supported the serological relatedness of the viruses and confirmed that the peplomer protein of FIPV type I has distinct structural features that differ from those of antigenically related viruses.
摘要
获得了覆盖I型猫传染性腹膜炎病毒（FIPV）KU - 2株纤突（S）基因整个区域的cDNA克隆，并测定了它们的完整核苷酸序列。在该基因中发现了一个编码1464个氨基酸残基的长开放阅读框（ORF），比II型FIPV 79 - 1146株的ORF长12个残基。对I型FIPV和主要II型FIPV的序列进行了比较。N端（氨基酸残基1 - 693）和C端（残基694 - 1464）两半的同源性分别为29.8%和60.7%。这远低于II型FIPV与其他抗原相关冠状病毒之间的同源性，如猪传染性胃肠炎病毒和犬冠状病毒。这支持了这些病毒的血清学相关性，并证实I型FIPV的纤突蛋白具有与抗原相关病毒不同的独特结构特征。
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