Gómez-Villamandos J C, Hervás J, Méndez A, Carrasco L, Villeda C J, Wilkinson P J, Sierra M A
Dpto Anatomía y Anatomía Patológica, Facultad de Veterinaria, Universidad de Córdoba.
Arch Virol. 1995;140(3):581-9. doi: 10.1007/BF01718433.
Despite the considerable attention given to kidney lesions in African swine fever (ASF), a number of questions remain to be answered. Structural and ultrastructural examination showed that a highly virulent isolate of ASF virus (Malawi 83) replicated in glomerular mesangial cells and renal collecting duct epithelial cells, with hyperplasia of the latter in infected pigs. Replication in mesangial cells may be due to their contact with the bloodstream, as well as to their phagocytic capacity and high metabolism rate. Virus replication in macrophages and endothelial cells of interstitial capillaries, and the necrosis of these infected cells gave rise to a large number of free virus in interstitial tissue. This, together with the lesser thickness of the basal membrane of collecting ducts in comparison to the rest of the tubular system, probably facilitates ASFV infection of tubular epithelial cells. Virus replication in these cells may account for the presence of virus in the urine of pigs with acute ASF where haematuria is not observed.
尽管非洲猪瘟（ASF）中的肾脏病变受到了相当多的关注，但仍有一些问题有待解答。结构和超微结构检查表明，一种高毒力的非洲猪瘟病毒分离株（马拉维83）在肾小球系膜细胞和肾集合管上皮细胞中复制，感染猪的后者会发生增生。在系膜细胞中的复制可能是由于它们与血液的接触，以及它们的吞噬能力和高代谢率。病毒在间质毛细血管的巨噬细胞和内皮细胞中复制，这些受感染细胞的坏死导致间质组织中产生大量游离病毒。这与集合管基底膜相比肾小管系统其他部分的厚度较薄一起，可能促进了非洲猪瘟病毒对肾小管上皮细胞的感染。这些细胞中的病毒复制可能解释了急性非洲猪瘟猪尿液中存在病毒但未观察到血尿的现象。
