Settipane G A, Chafee F H, Postman I M, Levine M I, Saker J H, Barrick R H, Nicholas S S, Schwartz H J, Honsinger R W, Klein D E
J Allergy Clin Immunol. 1976 Jun;57(6):541-6. doi: 10.1016/0091-6749(76)90004-x.
Of 38 patients with chronic urticaria of unknown etiology who were evaluated for food and drug additive sensitivity, 53% (20/38) had urticaria for 1 yr or more. Total eosinophil counts were not elevated in most patients, and the frequency of atopy was found to be similar to that in a general population. Of these 38 patients, 10 (26%) had a personal history of aspirin intolerance, but elimination of aspirin did not relieve the urticaria. In a double-blind crossover challenge with 0.22 mg of tartrazine and a control, tartrazine sensitivity was found in 8% (3/38) of patients with chronic urticaria and 20% (2/10) of patients with aspirin intolerance.
在对38例病因不明的慢性荨麻疹患者进行食物和药物添加剂敏感性评估时，53%（20/38）的患者荨麻疹病程达1年或更长时间。大多数患者的嗜酸性粒细胞总数未升高，且特应性疾病的发生率与普通人群相似。在这38例患者中，10例（26%）有阿司匹林不耐受的个人史，但停用阿司匹林并未缓解荨麻疹。在一项用0.22毫克酒石黄和对照进行的双盲交叉激发试验中，发现8%（3/38）的慢性荨麻疹患者和20%（2/10）的阿司匹林不耐受患者对酒石黄敏感。
