Stapleton F, Dart J K, Seal D V, Matheson M
Department of Optometry and Visual Science, City University, London.
Epidemiol Infect. 1995 Jun;114(3):395-402. doi: 10.1017/s0950268800052109.
This study evaluated the epidemiology of Pseudomonas aeruginosa keratitis in contact lens (CL) wearers; the relationships between CL storage case contamination and CL hygiene practice and between CL hygiene and the development of keratitis. Sixteen CL wearers with keratitis were compared with 44 asymptomatic controls. Lens hygiene practice was assessed and CL care materials, domestic water sites and endogenous sites were evaluated microbiologically. Poor CL hygiene was not associated with Ps. aeruginosa keratitis. There was an association between keratitis and bacterial contamination of the CL and storage case (P < 0.0005). Lens and storage case contamination were not significantly associated with poor hygiene. No domestic or endogenous source for Ps. aeruginosa was found. Causative organisms may be derived from other sources, but CLs and CL storage cases provide a favourable environment for Ps. aeruginosa colonization. Changing the CL care environment to one less favourable for Ps. aeruginosa may help to eliminate this problem.
本研究评估了隐形眼镜佩戴者中铜绿假单胞菌角膜炎的流行病学情况；隐形眼镜储存盒污染与隐形眼镜卫生习惯之间的关系，以及隐形眼镜卫生习惯与角膜炎发生之间的关系。将16名患角膜炎的隐形眼镜佩戴者与44名无症状对照者进行了比较。评估了镜片卫生习惯，并对隐形眼镜护理材料、家庭用水点和内源性部位进行了微生物学评估。不良的隐形眼镜卫生习惯与铜绿假单胞菌角膜炎无关。角膜炎与隐形眼镜及储存盒的细菌污染之间存在关联（P < 0.0005）。镜片和储存盒污染与不良卫生习惯无显著关联。未发现铜绿假单胞菌的家庭或内源性来源。致病生物可能来自其他来源，但隐形眼镜及其储存盒为铜绿假单胞菌定植提供了有利环境。将隐形眼镜护理环境改变为对铜绿假单胞菌不利的环境可能有助于消除这一问题。
