择期腹部手术后腹膜白细胞介素-6、白细胞介素-8及粒细胞弹性蛋白酶活性

Peritoneal interleukin-6, interleukin-8 and granulocyte elastase activity after elective abdominal surgery.

作者信息

Tsukada K, Takenoshita S, Nagamachi Y

机构信息

Department of Surgery I, Gunma University School of Medicine, Maebashi, Japan.

出版信息

APMIS. 1994 Nov;102(11):837-40. doi: 10.1111/j.1699-0463.1994.tb05242.x.

DOI:10.1111/j.1699-0463.1994.tb05242.x

PMID:7833003

Abstract

In this study we investigated the interleukin-8 concentration (IL-8) and granulocyte elastase activity (GE) after elective abdominal surgery. Postoperative interleukin-6 (IL-6), IL-8 concentrations and GE in the peritoneal fluid were examined in 27 patients who underwent various types of elective abdominal surgery. We compared these results with clinical parameters of surgical stress, operating time (OT) and blood loss during the operation (BL). P-IL-6 and P-IL-8 were significantly correlated with OT (P-IL-6; r = 0.67, P < 0.001: P-IL-8; r = 0.59, P < 0.001) and BL (P-IL-6; r = 0.61, P < 0.001: P-IL-8: r = 0.48, P < 0.01). P-IL-8 was significantly correlated with P-IL-6 (r = 0.68, P < 0.001) and there was a positive correlation between GE and P-IL-8 (r = 0.37, P < 0.05). These findings indicate that IL-8 might activate granulocytes in the peritoneal cavity after elective abdominal surgery and that assaying P-IL-6 and P-IL-8 is useful in assessing the host's response to surgical stress.

摘要

在本研究中，我们调查了择期腹部手术后的白细胞介素-8浓度（IL-8）和粒细胞弹性蛋白酶活性（GE）。对27例行各种择期腹部手术的患者的腹腔液术后白细胞介素-6（IL-6）、IL-8浓度及GE进行了检测。我们将这些结果与手术应激的临床参数、手术时间（OT）及术中失血量（BL）进行了比较。术后IL-6（P-IL-6）和IL-8与OT显著相关（P-IL-6；r = 0.67，P < 0.001；P-IL-8；r = 0.59，P < 0.001），与BL也显著相关（P-IL-6；r = 0.61，P < 0.001；P-IL-8：r = 0.48，P < 0.01）。P-IL-8与P-IL-6显著相关（r = 0.68，P < 0.001），且GE与P-IL-8呈正相关（r = 0.37，P < 0.05）。这些发现表明，IL-8可能在择期腹部手术后激活腹腔内的粒细胞，且检测P-IL-6和P-IL-8有助于评估宿主对手术应激的反应。