Kjeldsen-Kragh J, Haugen M, Borchgrevink C F, Førre O
Department of General Practice, University of Oslo, Norway.
Clin Rheumatol. 1994 Sep;13(3):475-82. doi: 10.1007/BF02242946.
We have previously reported that a significant improvement can be obtained in rheumatoid arthritis patients by fasting followed by an individually adjusted vegetarian diet for one year. The patients who changed their diet could be divided into diet responders and diet nonresponders. After the clinical trial the patients were free to change diet or medication and after approximately one year they were asked to attend a new clinical examination. We compared the change from baseline (i.e. at the time of study entry) to the time of the follow-up examination for diet responders, diet nonresponders and controls who ate an omnivorous diet. The following variables favoured diet responders: pain score, duration of morning stiffness, Stanford Health Assessment Questionnaire index, number of tender joints, Ritchie's articular index, number of swollen joints, ESR and platelet count [corrected]. The difference between the three groups were significant for all the clinical variables, except for grip strength. There was no significant difference between the groups with regard to laboratory or anthropometric variables. At the time of the follow-up examination all diet responders but only half of the diet nonresponders still followed a diet. Our findings indicate that a group of patients with rheumatoid arthritis benefit from dietary manipulations and that the improvement can be sustained through a two-year period.
我们之前曾报道，类风湿关节炎患者通过先禁食，然后采用个体化调整的素食饮食一年，病情可得到显著改善。改变饮食的患者可分为饮食反应者和饮食无反应者。临床试验结束后，患者可自由改变饮食或用药，大约一年后，他们被要求参加新的临床检查。我们比较了饮食反应者、饮食无反应者以及食用杂食的对照组从基线（即研究入组时）到随访检查时的变化。以下变量有利于饮食反应者：疼痛评分、晨僵持续时间、斯坦福健康评估问卷指数、压痛关节数、里奇关节指数、肿胀关节数、血沉和血小板计数[校正后]。除握力外，三组在所有临床变量上的差异均具有显著性。在实验室或人体测量学变量方面，各组之间无显著差异。在随访检查时，所有饮食反应者仍遵循饮食，但只有一半的饮食无反应者如此。我们的研究结果表明，一组类风湿关节炎患者可从饮食调整中获益，且这种改善可持续两年。
