单剂量磷霉素氨丁三醇与5天头孢氨苄方案治疗女性单纯性下尿路感染的疗效比较
Single-dose fosfomycin trometamol versus 5-day cephalexin regimen for treatment of uncomplicated lower urinary tract infections in women.
作者信息
Elhanan G, Tabenkin H, Yahalom R, Raz R
机构信息
Infectious Diseases Unit, Emek Medical Center, Afula, Israel.
出版信息
Antimicrob Agents Chemother. 1994 Nov;38(11):2612-4. doi: 10.1128/AAC.38.11.2612.
A randomized study was conducted to assess the clinical and microbiological efficacies of a single 3-g dose of fosfomycin trometamol for the treatment of uncomplicated lower urinary tract infections in women compared with a 5-day regimen of cephalexin at 0.5 g four times daily. One hundred twelve women, all of whom had documented infections with bacteria sensitive to both antibiotics, were included. Fifty-eight women received fosfomycin trometamol, and 54 women received cephalexin. The two groups did not differ in age, severity, or duration of current urinary tract infection, menstrual status, sexual activity, or use of contraceptives. Ninety percent of pathogens in the fosfomycin trometamol group and 81% in the cephalexin group were Escherichia coli (the difference is not significant [NS]). A clinical evaluation at the 5-day follow-up showed that 91% of the women in each group were free of symptoms, while five women in each group were considered therapy failures and were treated by another antibiotic course. A microbiological evaluation at the 5-day follow-up showed a 91% eradication rate in the fosfomycin trometamol group and an 83% eradication rate in the cephalexin group (NS). At the 1-month follow-up, a clinical evaluation demonstrated prolonged resolution in 86 and 78%, respectively, of the participating women (NS). A microbiological evaluation at 1 month demonstrated prolonged eradication in 47 (81%) women treated with fosfomycin trometamol and in 37 (68%) women treated with cephalexin (NS). Three and six women, respectively, had relapsed. No adverse reactions were reported by the fosfomycin trometamol-treated women, while three women treated with cephalexin reported mild adverse reactions but completed the study period. Fosfomycin trometamol in a single 3-g dose is as effective as a 5-day regimen of cephalexin for the treatment of uncomplicated lower urinary tract infection in women.
进行了一项随机研究，以评估单剂量3克磷霉素氨丁三醇治疗女性单纯性下尿路感染的临床和微生物学疗效，并与每日4次服用0.5克头孢氨苄的5天疗程进行比较。纳入了112名女性，她们均有对两种抗生素敏感的细菌感染记录。58名女性接受了磷霉素氨丁三醇治疗，54名女性接受了头孢氨苄治疗。两组在年龄、当前尿路感染的严重程度或持续时间、月经状况、性活动或避孕药使用方面没有差异。磷霉素氨丁三醇组90%的病原体和头孢氨苄组81%的病原体是大肠杆菌（差异不显著[NS]）。5天随访时的临床评估显示，每组91%的女性无症状，而每组有5名女性被视为治疗失败，并接受了另一疗程的抗生素治疗。5天随访时的微生物学评估显示，磷霉素氨丁三醇组的根除率为91%，头孢氨苄组为83%（NS）。在1个月随访时，临床评估显示，分别有86%和78%的参与女性症状持续缓解（NS）。1个月时的微生物学评估显示，接受磷霉素氨丁三醇治疗的47名（81%）女性和接受头孢氨苄治疗的37名（68%）女性持续根除病原体（NS）。分别有3名和6名女性复发。接受磷霉素氨丁三醇治疗的女性未报告不良反应，而接受头孢氨苄治疗的3名女性报告有轻微不良反应，但完成了研究期。单剂量3克的磷霉素氨丁三醇治疗女性单纯性下尿路感染的效果与5天疗程的头孢氨苄相同。
Zotero 插件