Bullock W E
J Immunol. 1976 Oct;117(4):1164-70.
Infection of Lewis rats with Mycobacterium lepraemurium is characterized by granulomatous pathology primarily involving the paracortical areas of lymph nodes and periarteriolar lymphocyte sheaths of the splenic white pulp. Intravenous infusion of radiolabeled thoracic duct lymphocytes (TDL)2 from normal syngeneic donors failed to produce a significant increase of cell output and radioactivity in the thoracic duct lymph of infected rats as compared with a marked increase in matched control recipients. Conversely, the migration of TDL from infected donor rats was normal in uninfected control rats that had been infused with serum from infected donors. The onset of the lymphocyte traffic disturbance takes place between 2 and 6 weeks after inoculation of viable M. lepraemurium. However, inoculation of heat-killed organisms produces little perturbation of lymphocyte circulation. Thus, the abnormal circulation of TDL in rats with active infection appears to be secondary to granulomatous pathology in lymphoid organs that disturbs cell traffic through these organs.
用鼠麻风分枝杆菌感染刘易斯大鼠的特征是肉芽肿性病理改变，主要累及淋巴结的副皮质区和脾白髓的动脉周围淋巴细胞鞘。与匹配的对照受体中放射性显著增加相比，从正常同基因供体静脉输注放射性标记的胸导管淋巴细胞（TDL）未能使感染大鼠胸导管淋巴中的细胞输出量和放射性显著增加。相反，在输注了感染供体血清的未感染对照大鼠中，来自感染供体大鼠的TDL迁移正常。淋巴细胞运输紊乱在接种活的鼠麻风分枝杆菌后2至6周出现。然而，接种热灭活的菌对淋巴细胞循环几乎没有干扰。因此，活动性感染大鼠中TDL的异常循环似乎继发于淋巴器官中的肉芽肿性病理改变，这种改变扰乱了细胞通过这些器官的运输。
