一项针对恶性肿瘤行胰腺大部切除术后全胃肠外营养的前瞻性随机试验。
A prospective randomized trial of total parenteral nutrition after major pancreatic resection for malignancy.
作者信息
Brennan M F, Pisters P W, Posner M, Quesada O, Shike M
机构信息
Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10025.
出版信息
Ann Surg. 1994 Oct;220(4):436-41; discussion 441-4. doi: 10.1097/00000658-199410000-00003.
Abstract
OBJECTIVES
The authors examined the impact of adjuvant total parenteral nutrition after major pancreatic resection for malignancy.
SUMMARY BACKGROUND DATA
Previous studies have suggested a benefit to perioperative nutritional support for patients undergoing major gastrointestinal surgery.
METHODS
A prospective, randomized study was conducted using patients who had undergone a major pancreatic resection with randomization on postoperative day one to either receive or not receive adjuvant total parenteral nutrition.
RESULTS
No benefit could be demonstrated by the use of adjuvant parenteral nutrition in this setting. Complications were significantly greater in the group receiving total parenteral nutrition. These complications tended to be those associated with infection.
CONCLUSIONS
Routine applications of postoperative parenteral nutrition to patients undergoing major pancreatic resection for malignancy cannot be recommended. Further studies are required to determine the reason that infectious complications in these patients are increased.
摘要
目的
作者研究了恶性肿瘤行胰腺大部切除术后辅助性全胃肠外营养的影响。
总结背景数据
先前的研究表明，对于接受大型胃肠道手术的患者，围手术期营养支持有益。
方法
进行了一项前瞻性随机研究，研究对象为接受胰腺大部切除术的患者，术后第一天随机分为接受或不接受辅助性全胃肠外营养两组。
结果
在这种情况下，使用辅助性胃肠外营养未显示出益处。接受全胃肠外营养的组并发症明显更多。这些并发症往往与感染有关。
结论
不建议对恶性肿瘤行胰腺大部切除术后的患者常规应用术后胃肠外营养。需要进一步研究以确定这些患者感染性并发症增加的原因。
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