Caramaschi P, Biasi D, Manzo T, Carletto A, Poli F, Bambara L M
Istituto di Clinica Medica, Policlinico Borgo Roma, Verona, Italy.
Rheumatol Int. 1995;14(6):253-5. doi: 10.1007/BF00262092.
The objective of this study was to determine the clinical features of 44 patients with anticentromere antibody (ACA) positivity. We undertook a retrospective review of 44 ACA-positive patients (1 male and 43 females with a mean +/- SD age of 53.6 +/- 12.2 years). There were 25 patients with limited systemic sclerosis, 12 with Raynaud's disease, 2 with Sjögren's syndrome, 2 with systemic lupus erythematosus and 3 with polyarthritis. ACA was more frequently found in patients affected by limited systemic sclerosis with mild visceral involvement and in patients with Raynaud's disease. Moreover, ACA was detected in other connective tissue diseases that were characterized by an atypical autoantibody profile.
本研究的目的是确定44例抗着丝点抗体（ACA）阳性患者的临床特征。我们对44例ACA阳性患者（1例男性和43例女性，平均年龄±标准差为53.6±12.2岁）进行了回顾性研究。其中有25例局限性系统性硬化症患者，12例雷诺病患者，2例干燥综合征患者，2例系统性红斑狼疮患者和3例多关节炎患者。ACA在伴有轻度内脏受累的局限性系统性硬化症患者和雷诺病患者中更常见。此外，在其他具有非典型自身抗体谱特征的结缔组织病中也检测到了ACA。
