单独使用2',3'-双脱氧肌苷以及与3'-叠氮-3'-脱氧胸苷联合使用时筛选出的猫免疫缺陷病毒多药耐药突变体
Multiple-drug-resistant mutants of feline immunodeficiency virus selected with 2',3'-dideoxyinosine alone and in combination with 3'-azido-3'-deoxythymidine.
作者信息
Gobert J M, Remington K M, Zhu Y Q, North T W
机构信息
Division of Biological Sciences, University of Montana, Missoula 59812.
出版信息
Antimicrob Agents Chemother. 1994 Apr;38(4):861-4. doi: 10.1128/AAC.38.4.861.
Abstract
Mutants of feline immunodeficiency virus (FIV) were selected in cell culture in the continuous presence of 10 microM (each) 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxyinosine (ddI). These mutants (AIR-1 and AIR-3) displayed a 13-fold resistance to AZT but had less than a 2-fold decrease in susceptibility to ddI. Interestingly, the AIR mutants were cross-resistant to phosphonoformate (PFA) and were hypersensitive to 2',3'-dideoxycytidine (ddC). Mutants of FIV were also selected in the presence of 10 microM ddI alone (DIS-1, DIS-2c), and these displayed a two- to fourfold decrease in susceptibility to ddI. Like the mutants selected with the combination of AZT plus ddI, DIS-1 and DIS-2c were cross-resistant to PFA and were hypersensitive to ddC. However, they remained as susceptible as wild-type FIV to AZT. Thus, the mutants selected with the combination of AZT plus ddI have phenotypes which reflect those obtained by selection with these drugs individually.
摘要
在细胞培养中，于持续存在10微摩尔（各）的3'-叠氮-3'-脱氧胸苷（AZT）和2',3'-双脱氧肌苷（ddI）的情况下筛选出猫免疫缺陷病毒（FIV）的突变体。这些突变体（AIR-1和AIR-3）对AZT表现出13倍的抗性，但对ddI的敏感性降低不到2倍。有趣的是，AIR突变体对膦甲酸（PFA）具有交叉抗性，并且对2',3'-双脱氧胞苷（ddC）高度敏感。FIV的突变体也在仅存在10微摩尔ddI的情况下被筛选出来（DIS-1、DIS-2c），并且这些突变体对ddI的敏感性降低了两到四倍。与用AZT加ddI组合筛选出的突变体一样，DIS-1和DIS-2c对PFA具有交叉抗性，并且对ddC高度敏感。然而，它们对AZT的敏感性仍与野生型FIV一样。因此，用AZT加ddI组合筛选出的突变体具有反映单独用这些药物筛选所获得表型的表型。
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2
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Antiviral Res. 1993 Dec;22(4):259-72. doi: 10.1016/0166-3542(93)90036-i.
3
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4
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5
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6
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