Alvarez P, Squire L R
Department of Psychiatry, University of California, San Diego, La Jolla 92093.
Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):7041-5. doi: 10.1073/pnas.91.15.7041.
Some forms of memory have been shown to depend on a system of medial temporal lobe structures that includes the hippocampus and the adjacent cortical areas (entorhinal, perirhinal, and parahippocampal cortex). The role of this system is only temporary, however, as indicated by the fact that, after damage to the medial temporal lobe, recent memories are impaired but very remote memories are intact. Here we review the evidence that the medial temporal lobe memory system is involved in a process of consolidation: memories are initially dependent on this system but gradually become established in other areas of the brain. We then review some of the ideas that have been proposed about the phenomenon of consolidation and suggest a synthesis of these views. Finally, we describe a simple neural network model that captures some key features of consolidation.
某些形式的记忆已被证明依赖于内侧颞叶结构系统，该系统包括海马体和相邻的皮质区域（内嗅皮质、嗅周皮质和海马旁皮质）。然而，这个系统的作用只是暂时的，内侧颞叶受损后，近期记忆受损但非常久远的记忆却完好无损这一事实就表明了这一点。在此，我们回顾内侧颞叶记忆系统参与巩固过程的证据：记忆最初依赖于这个系统，但逐渐在大脑的其他区域得以确立。然后，我们回顾一些关于巩固现象所提出的观点，并提出这些观点的综合。最后，我们描述一个捕捉巩固一些关键特征的简单神经网络模型。
