Minocha A, Siddiqi S, Rahal P S, Vogel R L
Department of Medicine, University of Louisville, Kentucky 40292.
Dig Dis Sci. 1994 Aug;39(8):1613-7. doi: 10.1007/BF02087764.
The pathogenesis of nonulcer dyspepsia (NUD) is unknown. Gas and postprandial bloating are frequent symptoms. The role of Helicobacter pylori (HP) in the pathogenesis of NUD is controversial. We studied the intestinal gas profile of NUD patients (N = 34) at baseline and after lactulose administration. The prevalence of hydrogen and methane producers was similar among HP+ and HP- patients. Breath H2 concentrations in response to lactulose showed significantly greater rise among HP+ subjects (P < 0.0001). HP positivity was associated with higher total breath excretion for H2 and methane combined (2984 +/- 1038 vs 1776 +/- 521 ppm/hr) compared to HP- subjects (P < 0.05). There was no correlation between peak H2 and methane levels. The role of alterations in intestinal gas in producing symptoms in HP+ patients with NUD needs further investigation.
非溃疡性消化不良（NUD）的发病机制尚不清楚。气体和餐后腹胀是常见症状。幽门螺杆菌（HP）在NUD发病机制中的作用存在争议。我们研究了34例NUD患者在基线时及服用乳果糖后的肠道气体状况。HP阳性和HP阴性患者中氢气和甲烷产生者的比例相似。HP阳性受试者对乳果糖反应的呼气H2浓度升高明显更大（P < 0.0001）。与HP阴性受试者相比，HP阳性与氢气和甲烷的总呼气排泄量更高相关（2984 +/- 1038对1776 +/- 521 ppm/小时）（P < 0.05）。H2和甲烷峰值水平之间无相关性。肠道气体改变在HP阳性NUD患者产生症状中的作用需要进一步研究。
