Fox J G, Dewhirst F E, Tully J G, Paster B J, Yan L, Taylor N S, Collins M J, Gorelick P L, Ward J M
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge 02139.
J Clin Microbiol. 1994 May;32(5):1238-45. doi: 10.1128/jcm.32.5.1238-1245.1994.
A bacterium with a spiral shape and bipolar, single, sheathed flagella was isolated from the livers of mice with active, chronic hepatitis. The bacteria also colonized the cecal and colonic mucosae of mice. The bacterium grew at 37 degrees C under microaerophilic and anaerobic conditions, rapidly hydrolyzed urea, was catalase and oxidase positive, reduced nitrate to nitrite, and was resistant to cephalothin metronidazole. On the basis of 16S rRNA gene sequence analysis, the organism was classified as a novel helicobacter, Helicobacter hepaticus. This new helicobacter, like two other murine Helicobacter species, H. muridarum and "H. rappini," is an efficient colonizer of the gastrointestinal tract, but in addition, it has the pathogenic potential to elicit persistent hepatitis in mice.
从患有活动性慢性肝炎的小鼠肝脏中分离出一种具有螺旋形状、两极单根带鞘鞭毛的细菌。该细菌还定殖于小鼠的盲肠和结肠黏膜。该细菌在微需氧和厌氧条件下于37℃生长，能快速水解尿素，过氧化氢酶和氧化酶呈阳性，将硝酸盐还原为亚硝酸盐，并且对头孢噻吩和甲硝唑耐药。基于16S rRNA基因序列分析，该菌株被分类为一种新型幽门螺杆菌，即肝螺杆菌。这种新的幽门螺杆菌与另外两种鼠源幽门螺杆菌——鼠幽门螺杆菌和“拉氏幽门螺杆菌”一样，是胃肠道的高效定殖菌，但此外，它还具有引发小鼠持续性肝炎的致病潜力。
