Franklin C L, Beckwith C S, Livingston R S, Riley L K, Gibson S V, Besch-Williford C L, Hook R R
Department of Veterinary Pathobiology, University of Missouri, Columbia 65211, USA.
J Clin Microbiol. 1996 Dec;34(12):2952-8. doi: 10.1128/jcm.34.12.2952-2958.1996.
A filamentous, gram-negative, motile bacterium with a single polar sheathed flagellum was isolated from gallbladders of hamsters with cholangiofibrosis and centrilobular pancreatitis. Bacteria grew under microaerophilic conditions at 37 and 42 degrees C, were oxidase, catalase, arginine aminopeptidase, and L-arginine arylamidase positive, reduced nitrate to nitrite, were resistant to cephalothin, and exhibited intermediate susceptibility to nalidixic acid. Sequence analysis of the 16S rRNA gene indicated that the bacterium was a novel member of the Helicobacter genus, most closely related to Helicobacter pametensis. We propose to name this bacterium Helicobacter cholecystus. In epidemiologic studies, isolation of H. cholecystus correlated strongly with the presence of cholangiofibrosis and centrilobular pancreatitis; however, further studies are needed to define the role of this bacterium in pathogenesis.
从患有胆管纤维化和小叶中心性胰腺炎的仓鼠胆囊中分离出一种丝状、革兰氏阴性、具单根极生鞘鞭毛的运动性细菌。该细菌在37℃和42℃的微需氧条件下生长，氧化酶、过氧化氢酶、精氨酸氨基肽酶和L-精氨酸芳基酰胺酶呈阳性，能将硝酸盐还原为亚硝酸盐，对头孢噻吩耐药，对萘啶酸呈中度敏感。16S rRNA基因序列分析表明，该细菌是螺杆菌属的一个新成员，与帕氏螺杆菌关系最为密切。我们提议将该细菌命名为胆囊螺杆菌。在流行病学研究中，胆囊螺杆菌的分离与胆管纤维化和小叶中心性胰腺炎的存在密切相关；然而，需要进一步研究来确定该细菌在发病机制中的作用。
