Chen Z, Liu S J, Cai S X, Yao Y M, Yin H, Ukai H, Uchida Y, Nakatsuka H, Watanabe T, Ikeda M
Institute of Occupational Medicine, Chinese Academy of Preventive Medicine, Beijing.
Occup Environ Med. 1994 Jan;51(1):47-9. doi: 10.1136/oem.51.1.47.
The health effects of exposure to a mixture of toluene and xylene isomers was studied on the fourth or fifth days of a working week in factories in China. The study population comprised 233 subjects (122 men and 111 women), who were exposed to the time weighted geometric mean (maximum) concentrations of toluene (3 (203) ppm) and xylenes (4 (103) ppm). For comparison, 241 non-exposed controls (116 men and 125 women) were recruited from the same regions. The prevalence of some subjective symptoms significantly increased in the exposed population, and the symptom profiles were similar to those found after exposure to toluene or xylenes alone. Haematology and serum biochemistry did not show notable changes. It seems reasonable to conclude that the effects of the toxicities of toluene and xylenes in combination are additive.
在中国的工厂里，于工作周的第四天或第五天研究了接触甲苯和二甲苯异构体混合物对健康的影响。研究对象包括233名受试者（122名男性和111名女性），他们接触的是时间加权几何平均（最大值）浓度的甲苯（3（203）ppm）和二甲苯（4（103）ppm）。作为对照，从同一地区招募了241名未接触者（116名男性和125名女性）。在接触人群中，一些主观症状的患病率显著增加，症状特征与单独接触甲苯或二甲苯后发现的相似。血液学和血清生化指标未显示出明显变化。可以合理地得出结论，甲苯和二甲苯毒性的联合作用是相加的。
