血管紧张素原作为日本原发性高血压的一个风险因素。
Angiotensinogen as a risk factor for essential hypertension in Japan.
作者信息
Hata A, Namikawa C, Sasaki M, Sato K, Nakamura T, Tamura K, Lalouel J M
机构信息
Department of Biochemistry, Nagoya City University Medical School, Japan.
出版信息
J Clin Invest. 1994 Mar;93(3):1285-7. doi: 10.1172/JCI117083.
Abstract
A common molecular variant of angiotensinogen (AGT), the precursor of the potent vasoactive hormone angiotensin II, has been incriminated as a marker for a genetic predisposition to essential hypertension in Caucasians (Jeunemaitre, X., F. Soubrier, Y. V. Kotelevtsev, R. P. Lifton, C. S. Williams, A. Charru, S. C. Hunt, P. N. Hopkins, R. R. Williams, J. M. Lalouel, and P. Corvol. 1992. Cell. 71:169-180). We now show that the same variant, T235, is associated with essential hypertension in Japanese patients. The observation of this association in a distinct, ethnically homogeneous population further substantiates an involvement of angiotensinogen in the pathogenesis of essential hypertension and has physiological, epidemiological, and evolutionary implications.
摘要
血管紧张素原（AGT）是强效血管活性激素血管紧张素II的前体，其一种常见的分子变体已被认定为高加索人原发性高血压遗传易感性的标志物（于内梅特雷，X.，F. 苏布里耶，Y. V. 科捷列夫采夫，R. P. 利夫顿，C. S. 威廉姆斯，A. 沙吕，S. C. 亨特，P. N. 霍普金斯，R. R. 威廉姆斯，J. M. 拉卢埃尔，以及P. 科尔沃。1992年。《细胞》。71卷：169 - 180页）。我们现在表明，相同的变体T235与日本患者的原发性高血压相关。在一个独特的、种族同质的人群中观察到这种关联，进一步证实了血管紧张素原参与原发性高血压的发病机制，并具有生理、流行病学和进化方面的意义。
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