在乙型肝炎病毒感染中检测到一种与 Dane 颗粒反应的新抗体系统。
Detection of a new antibody system reacting with Dane particles in hepatitis B virus infection.
作者信息
Alberti A, Diana S, Sculard G H, Eddleston A L, Williams R
出版信息
Br Med J. 1978 Oct 14;2(6144):1056-8. doi: 10.1136/bmj.2.6144.1056.
Antibodies in the serum reacting with antigens on the surface of radiolabelled Dane particles distinct from hepatitis B surface and core antigens (HBsAg and HBcAg) were detected, using a double antibody precipitation assay, in 12 out of 15 patients early in the course of acute type B hepatitis and at the time of disappearance of circulating Dane particles. No such antibody activity was found in 15 of the 16 patients with HBsAg-positive chronic active hepatitis, 13 of whom had complete Dane particles in the serum. In a group of 16 asymptomatic HBsAg carriers (without Dane particles in serum) antibody activity was shown in nine. This demonstration of antibodies precipitating Dane particles may be relevant to the clearance of circulating hepatitis B virions and the termination of infection in acute type B hepatitis. Their absence in all but one of the cases of chronic active hepatitis might explain why the virus infection persists in this group of patients.
利用双抗体沉淀试验，在15例急性乙型肝炎病程早期且循环中的丹氏颗粒消失时，检测到12例患者血清中的抗体与放射性标记的丹氏颗粒表面不同于乙肝表面抗原和核心抗原（HBsAg和HBcAg）的抗原发生反应。在16例HBsAg阳性慢性活动性肝炎患者中，有15例未发现此类抗体活性，其中13例血清中有完整的丹氏颗粒。在一组16例无症状HBsAg携带者（血清中无丹氏颗粒）中，有9例显示出抗体活性。这种沉淀丹氏颗粒的抗体的证明可能与循环中的乙肝病毒粒子的清除以及急性乙型肝炎感染的终止有关。除1例慢性活动性肝炎病例外，其余病例均未检测到此类抗体，这可能解释了为什么病毒感染在这组患者中持续存在。
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